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Schulz et al., 2000) and decreased DNA repair, and finally cell death

In addition, studies have shown that patients with COPD have increased intestinal permeability at rest and that performing activities of daily living (ADLs) leads to intestinal epithelial cell damage (63)

Mitotoxic agents can directly exert their effect on the mitochondria by inhibiting mitochondrial DNA [mtDNA] transcription, electron transport chain [ETC], and ATP synthesis ( Table 1 summarizes how different drug classes affect mitochondrial function and insulin sensitivity

SAM levels were decreased, but S-adenosylhomocysteine (AdoHcy, SAH) levels were elevated considerably, with global DNA hypomethylation observed in both heterozygotes and homozygotes 38