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Description

Brief Report: A Phase IIa, Randomized, Double-Blind, Placebo-Controlled Trial of Apilimod Mesylate, an Interleukin-12/Interleukin-23 Inhibitor, in Patients With Rheumatoid Arthritis

Science 375 , 671677 (2022)

GLP-1 is secreted by L cells in the ileum and GLP-1 receptors are found on the beta cells of the pancreas, in the intestine, and in the hypothalamus

Those antibodies could make future doses less effective, increase the risk of future reactions, or, in some therapeutic proteins, interfere with related natural proteins in the body