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Statements Acknowledgments We apologize for not being able to cite many relevant original papers, replaced by reviews, due to space limitation

Conclusion In conclusion, with the deepening understanding of epigenetics, more and more studies have demonstrated that DNMT-mediated aberrant methylation of genes plays an important role in the development of urinary system diseases

However, it is also confirmed, that a low-calorie diet combined with a moderate exercise program effectively lowers liver enzyme levels 42

We present data on liver size and question whether patients with normal or large liver volumes might survive without LT