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The studies included were obtained according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines ( The literature was searched in the online databases PubMed, Google Scholar, and Web of Science using the keywords Alzheimers disease (AD), vitamin C, and ascorbic acid (AA). The timeline of the searched literature was set for the last 21 years ranging from 2000 to January 2022

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Furthermore, RNA modifications, such as N6-methyladenosine (m6A) and 5-methylcytosine (m5C), are dynamically regulated by writer (e.g., METTL3, NSUN2), eraser (e.g., ALKBH5), and reader proteins (e.g., IGF2BP1/2, YTHDF1/2, YBX1), which modulate RNA splicing, stability, and translation [15,16,17]