foxo4-dri senolytic or senomorphic

foxo4-dri senolytic or senomorphic Class II senolytics inhibit survival pathways elicited by senescent Targeting cellular senescence with senotherapeutics:

Name: foxo4-dri senolytic or senomorphic Class II senolytics inhibit survival pathways elicited by senescent Targeting cellular senescence with senotherapeutics:
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Targeting cellular senescence with senotherapeutics: senolytics and senomorphics Zhang 2023 The FEBS Journal Wiley Online Library FOXO4 DRI regulates endothelial cell senescence via the P53 signaling pathway PMC Development of a novel senolytic by precise disruption of FOXO4 p53 complex eBioMedicine Peptide inhibitors targeting FOXO4 p53 interactions and inducing senescent cancer cell specific apoptosis bioRxiv

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The peptide also demonstrates cytoprotective properties by modulating the expression of genes involved in oxidative stress response and inflammatory cascades

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