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This form is not easily absorbed, produces a cyanide molecule that must be detoxified by the liver and it requires extra energy from our body for proper metabolism (22)

In support of this idea, when holoTC concentrations were subtracted from total vitamin B-12 concentrations, the remaining vitamin B-12, represented by the holohaptocorrin (holoHC) fraction of serum vitamin B-12, was unaffected by the concentration of plasma folate (Figure 8B)

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