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This can lead to irreversible neurological symptoms

In general, the majority of the CD38 NADase catalytic activity will generate nicotinamide, and a nearly stoichiometric amount of ADPR with residual amounts of NAD being converted to cADPR and nicotinamide [34-35, 38-40, 58-60]

This therapy is particularly effective for treating adolescent behavioral problems, substance use disorders, and mental health disorders like depression