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These changes suggest that ferroptotic stress disrupts mitotic progression, impairing the proliferative potential of lung cancer cells (75, 76)

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This results in excessive excitatory drive, characterized by downregulation of GABA signaling and upregulation of postsynaptic N-methyl-D-aspartate (NMDA) receptors, which has been shown to manifest as anxiety-like behaviors that persist across generations (111) (Figure 11)