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Keywords : Smoking, Senescence, Chronic obstructive pulmonary disease, Emphysema, microRNAs Chronic obstructive pulmonary disease (COPD) affects the health of more than 300 million people worldwide

TSNAs were reported in two studies, but at trace levels, which are similar to those found in a nicotine patch, and, most importantly, about 500-fold to 1400-fold lower than TSNA levels measured in regular cigarettes (E-cigs containing only 0.070.2% of the TSNAs present in cigarettes) (Table 1)

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