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[PubMed abstract] Ho RC, Cheung MW, Fu E, Win HH, Zaw MH, Ng A, et al

We dont recommend using the cream on a large surface area such as the legs or back since it can sometimes be confusing to patients how large of an area they can safely use this numbing cream on

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The remaining 40% is lost through other bodily functions, such as sweating, breathing, and fecal elimination