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(This also explains why aqueous-solubility models outperformed intrinsic-solubility models on the intrinsic-solubility test sets.) Nevertheless, using to predict pH-dependent solubility gives a good qualitative match with experiment, excepting cases where ion aggregation leads to lower-than-expected solubility

Anal Chim Acta 699:134152 Dempsey GA, Lyall HJ, Corke CF, Scheinkestel CD (2000) Pyroglutamic acidemia: a cause of high anion gap metabolic acidosis