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130,131 Most studies indicate that IDH2 is also significantly upregulated in ESCC, 132 ovarian cancer, 133 lung cancer and other types of cancer, 134 playing a pro-oncogenic role

The leading roles are usually played by the hormones estrogen, progesterone, and prolactin. Production and release of these hormones are regulated by several mechanisms, chiefly the pituitary gland

2 Aim of the work This study demonstrated the systemic effects of experimental hypothyroidism on the cardiac and hepatic physiological, biochemical, and structural changes in Wistar rats and compared the impacts of treating hypothyroid rats with L-thyroxine alone to that with sesame oil, whether alone or combined with hormone replacement, as an adjuvant therapy