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10.1158/1078-0432.CCR-12-2641 113 IsodaA.KairaK.IwashinaM.OriuchiN.TominagaH.NagamoriS.et al

Aging is accompanied by deteriorating proteostasis and altered modification landscapes, which compromise the reversible and dynamic property of LLPS, triggering the formation of aberrant, solid-like aggregates that exacerbate neuronal dysfunction and neurodegeneration