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Mansouri Y, Goldenberg G

MEVs can contain antigens that activate Toll-like receptors on epithelial or immune cells and increase blood-brain-barrier (BBB) permeability, thus facilitating the entry of bacterial byproducts in the brain (26, 29)

Because patients with PD already show reduced levels of protective Trp derivatives, further restriction could exacerbate this deficit and undermine AhR-mediated signaling