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Initiation and progression of PD is dependent upon cellular events, including failures in the protein degradation machinery, oxidative stress, mitochondrial dysfunction, defects in mitochondrial autophagy (mitophagy) and the continuous accumulation of -synuclein, driven through cell to cell interactions between glial cells and neurons that ultimately lead to apoptosis [7,10,18]

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doi: 10.1034/j.1601-183X.2003.00037.x 9 NicoliniCFahnestockM

For this reason, the sensitivity and specificity of protein concentrations for diagnosis of liver disease are far from ideal