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PloS One 8, e57971

10.1016/j.jddst.2022.103378 159 SheffeyV

DFR: Dihydroflavonol-4-reductase

Epigallocatechin-3-gallate (EGCG), a polyphenol found in green tea increases Nrf2 levels in MCF-7 and MDA-MB-231 breast cancer cell lines making them resistant to the inhibitory effects of paclitaxel and doxorubicin ( Bruceajavanica is a novel inhibitor ofNrf2 that sensitizes HER2-positive cancer cells to trastuzumab both in vitro and in vivo