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Chemicals: Solvents, inorganic salts, and organic reagents were purchased from commercial sources such as Sigma and Fisher and used without further purification unless otherwise noted

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Of note, the use of short-acting opioids to manage OWS in the United States during the fentanyl era has been limited to the hospital setting, given federal law restricting the use of full-agonist opioids to treat OUD outside of a federally certified OTP