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Using meta-regressionBayesian, regularized, trimmed (MR-BRT) 30 , we estimated RR functions for each alcoholoutcome relationship, relative to no consumption, with a spline ensemble, systematically trimming outliers, accounting for varying exposure intervals between comparison groups, adjusting for potential biases arising from known study-design characteristics, and incorporating remaining unexplained between-study heterogeneity into uncertainty estimates while accounting for small numbers of studies

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doi: 10.1038/nature14319 110 AlessioNRiccitielloFSquillaroTCapassoSDel GaudioSDi BernardoGet al