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The sermorelin and GHRP-6 articles cover alternative secretagogues that some protocols include

Oxidative stress and endothelial dysfunction Many disorders, such as hypertension, atherosclerosis, dyslipidemia, diabetes mellitus, CVD, renal failure, and ischemiareperfusion damage, are primarily caused by endothelial dysfunction and oxidative stress

There is also the question of what happens when GLP-1 therapy is eventually stopped: weight tends to return, suggesting that the underlying biology of obesity has not been fundamentally altered