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Dysregulation of this pathway is intimately linked to multiple neuropsychiatric and neurological disorders, including schizophrenia, major depressive disorder, cognitive impairment, neuropathic pain, and neurodegenerative diseases (Jovanovic et al., 2020

Grisold et al., 2012

Herein, using in vitro TNBC models including cell lines with GPX4 or PC suppressed, together with murine models of obesity and TNBC growth and metastasis, we aimed to characterize (i) interactions between GPX4, PC, and lipid oxidative stress in TNBC cells, and (ii) the effect of GPX4 suppression, alone or in combination with chemotherapy or immunotherapy, on TNBC progression

doi: 10.1021/jf050435b 3