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How drug repurposing can advance drug discovery: Challenges and opportunities

The affinity of the multivalent ligand 3 H-LSN3441732 for single K IV 7 ( K d = 2.8 nM) and K IV 8 ( K d = 2.0 nM) was lower compared with its affinity for K IV 78 ( K d = 0.21 nM) and K IV 58 ( K d = 0.33 nM), confirming that multivalency results in a substantial improvement in potency (Fig

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