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Alternative methods, such as combining pantoprazole with docetaxel in metastatic castration-resistant prostate cancer, showed that although safe, not every autophagy-targeting strategy achieves the established efficacy benchmarks, highlighting the importance of accurate patient stratification

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The authors would like to acknowledge the National Natural Science Foundation of China (81700055, R.T.), Natural Science Foundation of Jiangsu Province (BK20160229, R.T.), the Outstanding Talent Research Funding of Xuzhou Medical University (D2016021, R.T.), Postdoctoral foundation of Xuzhou Medical University (RC5052112, R.T.), National Natural Science Foundation of China (82241014, 82130002, Q.H.), Wuhan Science and Technology Bureau (2020020601012233, Q.H.), Supported by grants from the Ministry of Science and Technology of China (2021YFA0804803, K.S.) and the National Natural Science Foundation of China (81930012, 81730013, 81720108003, and 82130015, K.S.), the Research Start up Fund of Jining Medical University (Reference: 600791001, J.Y.)