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87,88,89 Results from studies on whether B12 can improve sleepwake rhythm have been mixed

One clinical trial of pregnant and lactating mothers found that mothers needed to consume 3 times the recommended amounts of vitamin B12 to maintain adequate vitamin B12 status throughout pregnancy and lactation

A sealed pen sitting in proper refrigeration is a completely different situation from a reconstituted vial that has been punctured three times and left on a bathroom counter