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Description

SKIN-LIGHTENING EFFECT The role of glutathione as a skin-lightening agent was accidentally discovered as a side effect during treatment of chronic diseases with glutathione.[] Various mechanisms have been proposed

In addition to the aforementioned HK2 inhibitors, natural extracts and their analogues such as Chrysin and Methyl Jasmonate are also in the preclinical research stage, although they might not have entered clinical trials due to side effects and other influencing factors (193, 194)

Vascular endothelial growth factor (VEGF), a typical marker of angiogenesis during wound healing, was quantitatively assessed via ELISA on day 3, revealing a significant increase in the G/D-CuP group (Fig