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Here, upon ASCL1 expression cells have to overcome a period of enhanced sensitivity to ferroptosis to fully transdifferentiate into neurons 78

However, the high concentration of sodium butyrate resulted in an osmolality of 0.79 Osmol/kg (37), which is at the upper limit of Caco-2 tolerance (38), possibly initiating stress responses

Metabolomic profiling confirmed AKT1-linked metabolic dysregulation, including altered levels of L-arginine, NADP+, ATP, guanosine, glycerol, and glutamate, indicating impaired redox balance and energy metabolism

This work was supported by the Open Project Fund of the Logistics Research Program (CZZ18J010)