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Secondly, while we statistically controlled for confounding factors, the potential influence of disease progression, medication use, and other unmeasured variables cannot be ruled out, particularly in patients with extended hospitalizations

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Thus, non-nucleotide inhibitors have been considered as an alternative approach for drug development

It is very likely that life-prolonging effect of spermidine goes beyond a simple increase in the number of days lived, and that relies on retardation of the manifestation of major age-associated diseases , like cardiac and arterial aging 106,114 , colon cancer 115 , neurodegenerative processes 116,117 , and its anti-inflammatory effects 112