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Spiering, R

Recent Findings Recent findings have increasingly highlighted the roles of neuroinflammation, dysregulation of the gut-brain axis, and poor sleep quality as key contributors to its pathophysiology

Kubota, H., Hayashi, H., Watanabe, T., Taguchi, Y

Under normoxic conditions HIF1 is hydroxylated and subsequently ubiquitinated for proteasomal degradation, whereas under hypoxic conditions its hydroxylation is blocked leading to its accumulation, dimerization with its beta subunit and subsequent translocation into the nucleus, where it regulates the expression of genes linked to cellular transformation, cell proliferation and angiogenesis [154156]