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Experimental perturbations in central-carbon metabolism that increase the KG/succinate ratio can enhance the activity of KG-dependent dioxygenases and bias embryonic stem (ES) cells and certain models of cancer towards differentiation 1,2,3

however, MitoQ, as an efficient mtROS scavenger, reduced the generation of mtROS and effectively inhibited the phosphorylation of Drp1, indicating that Drp1 is regulated by mtROS