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The t1/2F values of valproic acid in adult hepatic enzyme-uninduced healthy subjects and enzyme-induced epilepsy patients were calculated from five pharmacokinetic studies in which divalproex-ER was administered once daily for 614 days

Despite GSTP1 inhibition, the cause of insignificance in overall GST activity may be due to other GST isoforms remaining uninhibited, and compensatory mechanisms may upregulate other GST isoforms, indicating the need for further investigations

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