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6 The Many Complications of Chronic Kidney Disease CKD is associated with a wide range of significant health complications, including 64 : Cardiovascular Disease Cardiovascular disease, particularly advanced cardiovascular disease, is associated with a significantly elevated risk of various cardiovascular problems, such as hypertension (high blood pressure), arterial calcification (calcium buildup in the arteries), heart failure, valvular disease (damaged heart valves), and atherosclerosis

It exists in two stereoisomeric forms: D-carnitine, the inactive form, and L-carnitine, the biologically active form

Aromatase knockout (ArKO) inhibits endogenous E2 production and results in an obese phenotype in both male and female mice [154]

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