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Invest 120, 17911799

However, some studies reported that the level of phenylalanine was significantly increased in the CSF of MS-affected patients (105), whereas the concentration of arginine in the serum and CSF showed no obvious differences between patients with MS and healthy subjects (38), which contradicted our results

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However, several compounds have been tested, but none directly improved mitochondrial efficiency yet, and only partial amelioration of the phenotype has been reported (Penna et al., 2020)