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This hydrophobic appendage promotes non-covalent, high-affinity binding to circulating albumin, effectively turning the plasma protein into a reversible depot and raising the terminal half-life to roughly one week, compatible with once-weekly (OW) dosing in humans, which enhances accessibility compared to daily regimens [38]

Current diagnostic methods, such as computed tomography angiography, magnetic resonance angiography, and ultrasonography, are often costly and inaccessible in many healthcare settings

This is basically asking your insurance company for permission to cover the medication, especially if it's not automatically on their list of approved drugs

Abdominal pain was largely located in the right upper quadrant (RUQ) during AC, independent of IBD, cirrhosis or transplant (Fig 1B)