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Exploring the use of dimethyl fumarate as microglia modulator for neurodegenerative diseases treatment

However, both GPNA and V-9032 have notable drawbacks, including poor selectivity, a tendency for off-target effects, and cytotoxicity

The expression of adipogenic genes is decreased in obesity and diabetes mellitus

526 Additionally, the expression levels of ubiquitin-specific protease 11 (USP11) have been found to correlate with the development of aGVHD in patients undergoing allo-HSCT, suggesting that USP11 inhibition may be a viable strategy for both the prevention and treatment of aGVHD