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doi: 10.3389/fnut.2022.907789 107

Thus, PKC activated by Phorbol-12-myristate-13-acetate (PMA) catalyzes the phosphorylation of TGF, Amphiregulin and HB-EGF precursors facilitating their shedding mediated by ADAM17 and releasing the soluble growth factor outside the cell (Watanabe et al., 1992