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Zinc modulates calcium signaling by influencing the activity of ER calcium-release channels, including the ryanodine receptor (RyR) and the inositol 1,4,5-trisphosphate receptor (IPR) 62,63,64,65,66

Published online November , 3

However, prolonged or high-dose ketamine exposure induces a compensatory upregulation of NMDARs, increasing intracellular calcium ion influx and ROS production, ultimately leading to neuronal apoptosis ( In animal studies, antagonism of NMDA receptors in intermediate neurons of the forebrain and thalamus reduces GABAergic function