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Serum electrolytes, particularly potassium should be monitored closely - Anticoagulants: can increase or decrease the effects being necessary a dosage adjustment - Somatotropin: by inhibiting the response to this hormone Pregnancy and lactation Pregnancy: Safe use of this medicine in pregnancy has not been established

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Staying well-hydrated, eating a balanced meal before the injection, and managing expectations in the consultation can significantly reduce the chances of this becoming a problem or an anxious phone call

Figure 6: Kaplan-Meier Curves for Overall Survival in Non-Squamous NSCLC in Study JMEN Figure 7: Kaplan-Meier Curves for Overall Survival in Squamous NSCLC in Study JMEN Maintenance Treatment Following First-line Pemetrexed Plus Platinum Chemotherapy The efficacy of pemetrexed as maintenance therapy following first-line platinum-based chemotherapy was also evaluated in PARAMOUNT (NCT00789373), a multi-center, randomized (2:1), double-blind, placebo-controlled study conducted in patients with Stage IIIb/IV non-squamous NSCLC who had completed four cycles of pemetrexed in combination with cisplatin and achieved a complete response (CR) or partial response (PR) or stable disease (SD)