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Ubiquitin binding to UT3 cleft induces ubiquitin unfolding Extended Data Figure Legends ACKNOWLEDGMENTS We thank the staff of the BL-10U2 beamline at the National Center for Protein Sciences Shanghai at Shanghai Synchrotron Radiation Facility for support in X-ray diffraction and data collection, Yifei Zhao and Jiao Liu at the Protein Characterization and Crystallography Facility of Westlake University for assistance in crystallization and data processing, the High-throughput Screen Facility at Westlake University for use of the plate-reader equipment

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