CN108473484B - Compounds useful as modulators of TRPM8 - Google Patents Compounds useful as modulators of TRPM8 Download PDF Info Publication number CN108473484B CN108473484B CN201680070324 - -hydroxypoly (oxyethylene), - (P- (1,1,3, 3-tetramethylbutyl) phenyl) - -hydroxypoly (oxy)Ethylene) (greater than 1 mole), tetramethyl (+/-) -2,6,10, 10-tetramethyl-1-oxaspiro [4,5 ]]Deca-2, 6-dien-8-one, 1,5,5, 9-tetradecyl-13-oxatricyclo (8.3.0.0(4,9)) tridecane, 2,3,5, 6-tetramethylpyrazine, thaumatin B recombinant, spirane, theobromine, thiamine hydrochloride, thiamine mononitrate, thiazole, 2-thienyl disulfide, 1- (2-thienyl) ethanethiol, 2-thiophenethiol, 2-thienyl methanol, thioacetic acid, 2' - (thiodimethylene) -furan, thiodipropionic acid, thiogeranol, Nippon thistle (Jeffersonia simplicifolia), extract (Jeffeta indica), Nippon thistle (Jeffersonia simplicifolia), Nippon thistle (Jeffeta indica), L-threonine, Nippon thistle (Jeffeta indica), Nippon thistle, 4-thujaitol, thyme extract, thyme (thyme and thyme oil), thyme oil resin, thyme (thyme), wild or creeping thyme extract (thyme spread), thymol, titanium dioxide, alpha-tocopherol acetate, tocopherol, tolualdehyde glycerol acetal (mixed O-, M-, P-), tolualdehyde (mixed O-, M-, P-), toluol extract (cumin pigeon pea), toluol gum (cumin pigeon pea), O-toluol thiol, P-tolyl acetaldehyde, O-tolyl acetate, P-tolyl acetate, 4- (P-tolyl) -2-butanone, O-tolyl isobutyrate, P-tolyl isobutyrate, thyme oil resin, thyme (thyme), thyme oil resin, tolyl laurate, p-tolyl 3-methylbutyrate, p-tolyl acetate, 2- (p-tolyl) -propionaldehyde, O-tolyl salicylate, lycopene, tragacanth (Astragalus), (+/-) -trans-and cis-2-hexenal propanediol acetal, 2-trans-6-cis-dodecenal, 2-trans-6-cis-nonadienal, O-trans-coumaric acid, trans-2-dodecanol, trans-3-heptenyl acetate, trans-3-hexenol, trans-3-hexenyl acetate, trans-2-hexen-1-ylacetic acid, trans-2-hexenyl 2-methylbutyrate, p-tolyl propionate, p-tolyl propionate, 2- (, Trans-4-nonenal, trans-3-nonen-1-ol, trans-2-nonen-4-one, trans-2-nonenyl acetate, trans-4-octenoic acid, 2- (trans-2-pentenyl) cyclopentanone, trans-4-tert-butanol (Daghestan Sweetclover), trehalose dihydrate, triacetin (triacetin), acetyl tributyl citrate, trichloroethylene, tridecanal, tridecanoic acid, 2-deca Triketone, 2-trans, 4-cis, 7-cis-tridecenal, 2-tridecenal, tridodecylamine, triethanolamine, triethylamine, triethyl citrate, triethylenetetramine crosslinked with epichlorohydrin, trifluoromethanesulfonic acid, trichloroethylene, (trihydroxy-phenyl) -propan-1-one, trilobatin, trimethylamine oxide of trimethylamine, 2,6, 6-trimethyl-1 and 2-cyclohexene-1-carbaldehyde, P, , -trimethylbenzyl alcohol, 4- (2,6, 6-trimethylcyclohexa-1, 3-dienyl) but-2-en-4-one, 2,6, 6-trimethylcyclohexa-1, 3-diencarbaldehyde, 5-trimethylcyclohexanol, 2, 6-trimethylcyclohexanone, 2,6, 6-trimethyl-1-cyclohexen-1-al-dehyde, 2,6, 6-trimethylcyclohex-2-ene-1, 4-dione, 4- (2,6, 6-trimethylcyclohex-1-enyl) but-2-en-4-one, 3, 5-trimethylcyclohexyl ester, 2, 3-trimethylcyclopent-3-en-1-ylacetal, 4- (2,2, 3-trimethylcyclopentyl) butyric acid, 3,7, 11-trimethyldodecane-2, 6, 10-trienylacetate, 3,5, 5-trimethylhexanal, 3,5, 5-trimethyl-1-hexanol, 2,6, 6-trimethyl-2-hydroxycyclohexanone, (2,6, 6-trimethyl-2-hydroxycyclohexylidene) acetate
It can also reduce the levels of FAS, caspase-3, AST, ALT, GGT and ALP to alleviate liver inflammation and oxidative stress
X., Peng, Y
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