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A double-blinded randomized clinical trial with 9 to 14 years follow-up

To clarify the causal relationships and stagedependent roles of these factors, we propose a conceptual framework for AD progression (1):Early AD (causal events): Disruption of cerebral iron homeostasis leads to regional iron accumulation, which primes neurons for ferroptosis through elevated ROS and impaired antioxidant defenses (2).Transitional AD (facilitative events): Ferroptotic stress promotes A aggregation and tau hyperphosphorylation

doi: 10.1007/s00018-010-0460-1

In general, nootropics are cognitive enhancers initially developed to address cognitive impairments