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Pharmaceutical development of Nrf2 modulators The identification of Nrf2 as a master regulator of cellular antioxidant defenses has revolutionized our understanding of its pivotal role as a therapeutic target in the pathogenesis of inflammatory diseases

2018;29:iv51iv67

These data revealed that cytotoxic chemotherapeutic agents with different mechanisms of action, including taxanes and platinum-containing compounds, can trigger senescence of normal and malignant cells in different tissues in vivo that may worsen prognosis of the disease

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