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In contrast, GSTP1 promoter remains almost unmethylated in benign lesions, allowing distinguishing benign and cancerous transformations ( Lung cancer Leukemia and lymphoma Breast cancer Jhaveri and Morrow initially published that methylation status of GSTP1 promoter contributes significantly to the levels of GSTP1 expressed in ER-negative and ER+-positive breast cancer cell lines ( Liver cancer According to Other cancer subtypes Similarly, the invasion potential of pituitary tumors and endometrial carcinomas was linked to reduction of GSTP1 expression and methylation frequency, indicating that epigenetically mediated down-regulation of GSTP1 expression may also contribute to aggressive pituitary tumor behavior ( PATHOLOGICAL ALTERATIONS OF GSTP1 METHYLATION PATTERNS Beyond DNA hypermethylation, which was the first epigenetic alteration to be discovered as an influencing factor for GSTP1 expression, histone modifications were discovered in the early 2000 s to play a regulating role in GSTP1 expression

The first Glp1 came out in 2005 so it took 20 years to get things where they are today