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The high antiradical efficacy of the flavonoid complexes is due to the ability of chelated metal ion to operate as a superoxide scavenger with dismutating activity, in accord with the following reactions: (n+1)+ + 2 n+ + 2 (10) n++ 2 + 2H+ (n+1)+ + H22 (11) Apparently, the flavonoid molecules are able to react with metal ions directly in blood stream or tissues

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First, normal aging is associated with the progressive dysregulation of iron homeostasis, often leading to iron accumulation in vulnerable brain regions such as the hippocampus and substantia nigra (52)

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