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Dietrich MO, Bober J, Ferreira JG, Tellez LA, Mineur YS, Souza DO, Gao XB, Picciotto MR, Arajo I, Liu ZW, Horvath TL

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Inhibiting oxalate formation curbs inflammation and fibrosis Considering that AGXT overexpression attenuated hepatic inflammation and fibrosis in MASH, we next sought to determine whether the pharmacological targeting of hepatic oxalate overproduction in mice with established MASH is sufficient to suppress proinflammatory and profibrotic responses