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Exposure to TBHP induced a pronounced increase in intracellular ROS after 4 hours, consistent with oxidative stress-mediated injury commonly reported in airway epithelial cells exposed to pollutants or inflammatory mediators [34,35]

45 To date, however, no evident functional connection has been identified between OP-associated neurobehavioral deficits and inflammatory response

On the other hand, the level of guanosine monophosphate was found to be modulated along with carbamoyl phosphate in mild to severe patients, suggesting the role of immune dysfunction and nucleotide metabolism in the progression of non/severe COVID-19 to severe condition 9

Beppu AK, Zhao J, Yao C, Carraro G, Israely E, Coelho AL, Drake K, Hogaboam CM, Parks WC, Kolls JK, et al