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Midlife stressors and lifestyle changes like irregular sleep, an increase in alcohol and caffeine, and low muscle mass can contribute to a dysregulation of our cortisol threshold

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15 BM-MSCs have been demonstrated to better tolerate the hypoxic IVD environment as low O 2 upregulates the hypoxia-inducible factor 1 and yes-associated protein pathways resulting in increased proliferation, stemness preservation, and protection from apoptosis