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Disclosures: Swati Ghosh: Nothing to Disclose, Michael Devereaux: Nothing to Disclose, Aimee Anderson: Nothing to Disclose, David Orlicky: Nothing to Disclose, Ronald Sokol: Nothing to Disclose 2476 INTERLEUKIN 8-CXCR2 MEDIATED NEUTROPHIL EXTRACELLULAR TRAP (NET) FORMATION IN BILIARY ATRESIA ASSOCIATED WITH NET-INDUCED STELLATE CELL ACTIVATION Cara Mack 1 Yuhuan Luo 2 Julia Jezykowski 1 Lisa Fraser 1 Nitika Gupta 3 Alexander Miethke 4 Sarah Taylor 5 Estella Alonso 6 Simon Horslen 7 Rohit Kohli 8 Jean Molleston 9 Binita Kamath 10 Stephen Guthery 11 Kathleen Loomes 12 John Magee 13 Philip Rosenthal 14 Pamela Valentino 15 Ronald Sokol 16 , 1 Medical College of Wisconsin, 2 University of Colorado Denver, 3 Emory University School of Medicine, 4 Cincinnati Children's Hospital Medical Center, 5 Columbia University Medical Center, 6 Ann & Robert H

Drug delivery of DNA origamis is limited due to denaturation, dissociation in the tumor microenvironment, and nuclease degradation, further limiting its industrialization 22,88

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