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Part 4 Section 11 Management Strategy 3: Medications Atropine Learning Objectives Atropine: Mechanism of Action Diagnostic Use: The Atropine Challenge Atropine: Available Forms (Optional Reading) Atropine: Stability of Solution (Optional Reading) Atropine: Route of Administration Misconception Reality Reasons Why Signs of Atropinism Are Not the Appropriate End Point to Guide Atropine Treatment Atropine Dose Misconception Reality Total Doses of Atropine in Poisoning with Organophosphorus Compounds (Optional Reading) Extremely High Total Doses of Atropine May be Needed in Suicidal Ingestions of Organophosphorus Compounds (Optional Reading) Nerve Agents Require Lower Total Doses of Atropine (Optional Reading) Carbamates Require Lower Doses (Optional Reading) Atropine: Low Incidence of Adverse Effects Alternatives to Atropine (Optional Reading) Key Points Progress Check Upon completion of this section, you should be able to identify the: Mechanism by which atropine counters the effects of the cholinergic toxidrome

doi:10.1016/j.euroneuro.2015.01.014