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The consumption of acetyl-CoA in irreversible metabolic pathways, i.e., lipoic acid and citrate synthesis within the mitochondria followed by biosynthetic processes within the cytosol (Figure 1), drives the process and maintains the mitochondrial content of acetyl-CoA within a safe range

for 5 days) was reported to attenuate diethylnitrosamine (DENA)-induced liver carcinogenesis and reduce serum AFP and VEGF levels and liver HGF protein in rats [94]

Collectively, researchers proposed a robust alternative to neo-adjuvant and adjuvant immunotherapies which are only limited to certain cancer therapies, thus offering a facile advancement of exploiting low and prolonged RNA immunotherapeutic loaded hydrogels delivery vectors with broad spectrum biomedical applications from wound healing to anticancer and cardioprotective function against myocardial infraction