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The practice of living as a pathogen within the host can be divided into six junctures, including (i) the association of bacterium with microvilli on the plasma membrane, (ii) internalization by professional and non-professional phagocytes, (iii) escape from the entry vacuole, (iv) replication in the cytosol, (v) propelled to the cell surface with the help of host actin filaments and form pseudopod-like structure, and (vi) spread through the cell to cell, forming a double-membrane vacuole ( Figure 5 ) (Tilney and Portnoy, 1989