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871 Oxidative stress is characterized by MDA and 4-HNE, and their roles in cartilage degeneration and subchondral bone remodeling during OA development have received extensive attention

DECLARATIONS Research in the authors lab has been supported by The University of Texas MD Anderson Cancer Center, National Institutes of Health grants R01CA181196, R01CA244144, and R01CA247992 (to BG), and Cancer Center Support (Core) Grant P30 CA016672 from the National Cancer Institute, National Institutes of Health (to The University of Texas MD Anderson Cancer Center)

Mice were used under the protocols M1900034, V1800106, and V2000018 approved by the IACUC at Vanderbilt University and Institutional Biosafety Committee and the Research and Development Committee of the Veterans Affairs Tennessee Valley Healthcare System